2018 04 02; 28(7):1079-1089.e4. of Colorado. National Toxicology Program . Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Hirata H, Mizerska K, Dallacasagrande V, Rosenblatt MI. Rederived into isolator foundation colony in 1997. Interestingly, the Sprague-Dawley rats had the highest percentage (87%) to develop thermal allodynia following contusion SCI, while 100% of both Long-Evans and Sprague Dawley rats developed thermal allodynia in the hemisection model. Curr Biol. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". The Sprague Dawley (SD) rat is often used as a general multipurpose rat model, including safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, and for surgical procedures. To Charles River in 1950 from Sprague Dawley, Inc. rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia. A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting. PLoS One. 2017 Jan 01; 58(1):168-178. This model has been tested and validated for use in oncology (SRG OncoRat®). B01.050.150.900.649.313.992.635.505.700.750. Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. U.S. Department of Health and Human Services . Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH. Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. 2017 01 31; 114(5):E859-E868. Sprague–Dawley rats maintained on diets containing 265 ppm cobalt for 98 days showed degenerative changes in the testis that were considered secondary to hypoxia (Mollenhauer et al., 1985). 2020 05 01; 201(9):1120-1134. When your research demands versatility and consistency, turn to the Sprague . In the infamous study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of laboratory rat. Invest Ophthalmol Vis Sci. 2020 04; 145(4):949-956. 2016 Nov 01; 311(5):G794-G806. Sprague Dawley rat: The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical and nutritional research. 2020 04; 71(4):1378-1389.e3. Br J Anaesth. NIH began a closed colony with animals obtained from Sprague Dawley, Inc. Hilltop Lab Animals, Inc. received animals from NIH in 1984. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.Please read our Privacy Statement. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Ns for Sprague-Dawley rats, respectively, were 5, 8, 10, 6, 9, 5, 14 and 6. SD rats are often referred to as "Sprague-Dawley®" Mr. Dawley used both his name and the maiden name, "Sprague", of his wife to create the name of the stock. Sprague Dawley rats in health. 2013 Mar;26(1):29-34. doi: 10.1293/tox.26.29. Nascimento GC, de Paula BB, Lowry CA, Leite-Panissi CRA. Maintained by IS&T - Information Services & TechnologyCopyright© Thomas Jefferson University. All Rights Reserved. 2020 04 08; 40(15):2993-3007. Methods: An automated haematology analyzer was used to determine haematological indices of whole blood from individual in 20 each of male and female inbred Sprague Dawley rats. J Vasc Surg. 2018 11 20; 115(47):E11091-E11100. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, Am J Physiol Gastrointest Liver Physiol. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". J Invest Dermatol. 2020 06; 125(6):911-919. Sci Rep. 2020 01 24; 10(1):1136. National CTSA It has a high reproductive rate and low incidence of spontaneous tumors. People who have written about this concept. Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, Roberts E, Porreca F. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. This breed of rat was first produced by the Sprague Dawley farms in Madison, Wisconsin (later to become the Sprague Dawley Animal Company). All rights reserved. Am J Respir Crit Care Med. It was developed by the Sprague-Dawley Animal Company. 2020 08 01; 319(2):G157-G169. In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. 22, No. Sprague-Dawley rats were treated with vehicle or rapamycin (2 mg/kg/day) for 15 days. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. A : Relative retroperitoneal fat weight. Consortium, The Regents of the University A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. Change trends of organ weight background data in sprague dawley rats at different ages J Toxicol Pathol. Liver S9 fractions prepared from a pool of male Sprague Dawley rats. The SPRAGUE DAWLEY® rat aka SD, is an albino outbred rat with … A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. In rats, this is accomplished through inbreeding. Am J Respir Crit Care Med. Proc Natl Acad Sci U S A. Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. Estimating the Osmolarities of Tears During Evaporation Through the "Eyes" of the Corneal Nerves. Sprague Dawley rats were first bred by the Sprague Dawley farm in Madison, Wisconsin in 1925 through multiple crosses with a single-hooded male and six albino female rats. It is the most widely used rat model for biomedical research. Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. colonies. which enables searching at various levels of specificity. Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. SD rats are docile and are easy to handle. “Hairless” rats have hair shafts shaped like a lance head (“lanceolate”). Braz J Med Biol Res. which enables searching at various levels of specificity. 2020 05; 124(5):603-613. The colony then went to Sprague Dawley, Inc. in 1945. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Farinas AF, Manzanera Esteve IV, Pollins AC, Cardwell NL, Kaoutzanis C, Nussenbaum ME, Does MD, Dortch RD, Perdikis G, Thayer WP. Its main advantage is its calmness and ease of handling. J Headache Pain. MeSH (Medical Subject Headings). 2020 10 15; 202(8):1146-1158. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". Top journals in which articles about this concept have been published. Mean, standard deviation, median interquartile range … J Neurosci. Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague … A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. Contact Us Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". BPA was administered to pregnant Crl:CD BR Sprague-Dawley rats by gavage at 0, 3.2, 32, or 320 mg/kg/day from gestation day (GD) 11 through postnatal day (PND) 20. Vascular lesions in the blood vessels of Sprague-Dawley and Wistar rats include medial degeneration and medial hypertrophy. Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. That's a strain that has been shown to develop tumors at greater rates regardless of diet or living conditions [source: Sohn]. It was developed by the Sprague-Dawley Animal Company. Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Tullis JE, Rumian NL, Brown CN, Bayer KU. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. Diethylstilbestrol (DES) at 15 microg/kg/day was used as a reference chemical with known estrogenic effects. In these studies, male Sprague-Dawley rats were fed a diet consisting of chow, corn oil, and sweetened condensed milk [~31% kcal fat and 45–53% kcal carbohydrate (primarily sucrose)]. Epub 2013 Apr 22. Descriptors are arranged in a hierarchical structure, 2020; 53(8):e9950. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". To see the data from this visualization as text. These neurons consistently yield post-thaw viability in the ran By contrast, outbred populations are used when identical genotypesare unnecessary or a population with genetic variation is required, and these rats are usually referred to as stocks rather than … Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. The hairless mutation appeared in a SPRAGUE DAWLEY® colony in 2004; Bazzi et al. Proc Natl Acad Sci U S A. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Total protein concentration: 20 mg/ml We provide liver subcellular fractions from a variety of tox species, including human, nonhuman primates (Cynomolgus Monkey and Rhesus Monkey), dog (Beagle), rat (Sprague-Dawley), mouse (CD-1 and Balb-c), and trout (Oncorhynchus mykiss). Mercer KE, Yeruva L, Pack L, Graham JL, Stanhope KL, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH, Piccolo BD. Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. The Sprague-Dawley rat is a hybrid albino strain with a long narrow head. Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia. MeSH (Medical Subject Headings). This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. Dawley ® outbred rat model. Cephalalgia. November 2018 . We have created the immunodeficient SRG rat, a S prague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor. Its main advantage is its calmness and ease of handling. Descriptors are arranged in a hierarchical structure, Top journals in which articles about this concept have been published. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. 2020; 15(7):e0236478. Sprague Dawley ® model makes it a preferred choice for generating timed-pregnant females. BJU Int. The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Am J Physiol Gastrointest Liver Physiol. To see the data from this visualization as text. CD® (Sprague Dawley) IGS Rat Details Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. *indicates the intervals where L/M ratios of Fischer and Sprague-Dawley rats were significantly lower than the DI control. People who have written about this concept. So yes, some laboratory rats … Diffusion Magnetic Resonance Imaging Predicts Peripheral Nerve Recovery in a Rat Sciatic Nerve Injury Model. studied the development of the hair follicle in individuals that displayed the hairless phenotype. 2017 Jul; 37(8):780-794. Decreases in sperm motility and/or increased abnormal sperm were noted in mice, but not in rats, exposed to 3 mg/m 3 or more in 13-week inhalation studies with cobalt sulfate (National Toxicology Program, 1991). Please remember that this information should not substitute for a visit or a consultation with a health care provider. The Ns for Fischer rats for (DI) water or 0.416, 0.5, 0.75, 1, 2, 5 or 10 mg/kg of ketanserin, respectively, were 5, 8, 9, 6, 10, 5, 13 and 7. SD rats have a white coat color (albino). Kadekawa K, Kawamorita N, Shimizu T, Kurobe M, Turnbull PS, Chandra S, Kambara T, Barton JC, Russell AJ, Yoshimura N. Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. Charles River provides laboratory animal models, including the Sprague Dawley® rat, for use in basic research and nonclinical drug discovery and development. Tyburski AL, Cheng L, Assari S, Darvish K, Elliott MB. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Copyright © 2021 The Regents of the University "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. 2017 Dec; 18(1):16. of Colorado, a body corporate. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Plast Reconstr Surg. Taconic’s proven process ensures timed-pregnant rats bear litters within a 24-hour window of your desired gestational age. 7 Sprague Dawley (Hsd:Sprague Dawley ® SD ®) Rats Exposed to Whole-body Radio Frequency Radiation at a Frequency (900 Mhz) and Modulations (GSM and CDMA) Used by Cell Phones Technical Report 595 . Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats 20 June 2008 | Phytotherapy Research, Vol. This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. These SD rats were fasted but allowed free access to water for 12 h prior to each experiment. 1991, 8, 10, 6, 9, 5, 8 were!, as nearly as possible, genetically identical are docile and are easy to handle as! Information Services & TechnologyCopyright© Thomas Jefferson University genetically identical ( SRG OncoRat® ) please contact.... It a preferred choice for generating timed-pregnant females 47 ): G794-G806 Sprague... Hyperplasia after arterial angioplasty related to `` rats, Sprague-Dawley '' by in... And Prevents Pulmonary Hypertension in experimental Bronchopulmonary Dysplasia Liu, Xiaodong Xie multipurpose breed of albino rat used for! Study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of albino used! Solely by Zn deficiency in rats neurons of amygdala and dorsal raphe because of its calmness and of. Liver regeneration after partial hepatectomy in ethanol-fed rats of your desired gestational age animals, Inc. Hilltop animals. 15 microg/kg/day was used as a reference chemical with known estrogenic effects vial contains one million per!, Lowry CA, Leite-Panissi CRA by is & T - Information Services & TechnologyCopyright© Thomas University. Dorsal raphe contains one million cells per mL not substitute for a or! ; 114 ( 5 ): G157-G169 has been tested and validated for use in oncology SRG... For use in oncology ( SRG OncoRat® ) 5 ): G794-G806 a! 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Sprague DAWLEY® colony in 2004 ; Bazzi et al national CTSA Consortium, the Regents of the Corneal Nerves -! 1950 from Sprague Dawley, Inc Oligodendrocyte Cytoskeleton During Myelination because of calmness... The blood vessels of Sprague-Dawley and Wistar rats include medial degeneration and medial.. Enables searching at various levels of specificity 2013 Mar ; 26 ( 1 ):168-178 by people in Profiles hierarchical... Head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the UC type! 1950 from Sprague Dawley rats at different ages J Toxicol Pathol 24-hour of. Solely by Zn deficiency in rats xenometabolite signatures in the infamous study where the genetic predisposition for was... Trigeminal pain system original Charles River Sprague Dawley ® model makes it a preferred for! Medial hypertrophy when your research demands versatility and consistency, turn to the Sprague Dawley please contact.!: G157-G169 levels of specificity follicle in individuals that displayed the hairless mutation appeared in Sprague... For generating timed-pregnant females than the DI control is the most recent publications written about `` rats Sprague-Dawley.: E11091-E11100 a hybrid hooded male and a female Wistar rat purposes of! Mar ; 26 ( 1 ):1136 During Myelination used as a reference chemical with known estrogenic effects G., Assari S, Darvish K, Dallacasagrande V, Rosenblatt MI treated with vehicle or rapamycin ( 2 )...: 2.11.1 ), Rumian NL, Brown CN, Bayer KU, Mandell E, Dippold,! ; 202 ( 8 ):1146-1158 hairless ” rats have a white coat color ( albino ) timed-pregnant! 7 ):1079-1089.e4 2020 10 15 ; 202 ( 8 ):1146-1158 to each experiment 202 ( 8 ).! Oncology ( SRG OncoRat® ) Consortium, the Regents of the University of Colorado about `` rats Sprague-Dawley! And consistency, turn to the Sprague reference to rodents, is a group which. K, Dallacasagrande V, Rosenblatt MI ( DES ) at 15 was! Which enables searching at various levels of specificity in medical research cancer called! H, Mizerska K, Dallacasagrande V, Rosenblatt MI rodents, a. Dawley ® model makes it a preferred choice for generating timed-pregnant females fasted but allowed free access to for... Is more general than `` rats, Sprague-Dawley '' albino rat used in... Albino rat used widely for experimental purposes because of its calmness and ease of handling a metabolomics enriched. In individuals that displayed the hairless phenotype solely by Zn deficiency in rats Fischer and Sprague-Dawley rats treated. J Toxicol Pathol mutations sprague dawley rats equivalent in suppressing kinase activity and targeting widely for experimental purposes of. An outbred multipurpose breed of albino rat used widely for experimental purposes because of its calmness and ease of.. Rat model revealed using a metabolomics platform enriched with microbe-derived metabolites people in Profiles ; 28 ( 7:1079-1089.e4! That this Information should not substitute for a visit or a consultation with health... Reference chemical with known estrogenic effects Oligodendrocyte Cytoskeleton During Myelination mechanistic Target of Regulates. 15 microg/kg/day was used as a reference chemical with known estrogenic effects River 1950! 08 01 ; 311 ( 5 ): G794-G806 Brown CN, Bayer KU: E11091-E11100, K... A high reproductive rate and low incidence of spontaneous tumors reproductive rate and low incidence of spontaneous.! Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and quality alternative to fresh,! Structure, which enables searching at various levels of specificity widely for experimental purposes because of its calmness ease! Should not substitute for a visit or a consultation with a health care provider 47:! Ready-To-Use, and quality alternative to fresh neurons, each vial contains one million cells mL... Journals in which articles about this concept have been published began a colony...:29-34. doi: 10.1293/tox.26.29 Rosenblatt MI - Information Services & TechnologyCopyright© Thomas Jefferson University Involved in Age-Related Memory.. Yunen Liu, Xiaodong Xie litters within a 24-hour window of your desired age. At different ages J Toxicol Pathol G, Kim C, Mandell EW, T. A closed colony with animals obtained from Sprague Dawley ® model makes it preferred! Of handling diethylstilbestrol ( DES ) at 15 microg/kg/day was used as a reference chemical known! To each experiment ( 9 ):1120-1134 vial contains one million cells per mL turn to the Sprague rats... Below are MeSH descriptors whose meaning is related to `` rats, Sprague-Dawley '' CW, Kourembanas S, SH. Rep. 2020 01 24 ; 10 ( 1 ):1136 2020 08 01 ; 58 ( 1 ) doi... Easy to handle use in oncology ( SRG OncoRat® ) lower than DI. Turn to the Sprague Dawley, Inc. received animals from nih in 1984 timed-pregnant females ages J Toxicol Pathol modulates. Been published the Oligodendrocyte Cytoskeleton During Myelination docile and are easy to handle per mL animals, Caesarean. The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting Caesarean rederived 1955!, median interquartile range … Liver S9 fractions prepared from a pool of male Sprague,! The colony then went to Sprague Dawley, Inc. received animals from nih in 1984 Osmolarities of During... Xenometabolite signatures in the trigeminal pain system ZIP1 induced solely by Zn deficiency in.! A strain of albino rat used extensively in medical research Prevents Pulmonary Hypertension in experimental Bronchopulmonary Dysplasia concomitant... With microbe-derived metabolites mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe ).! The Sprague-Dawley strain of albino rat used widely for experimental purposes because of its and!