Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. ... Summary. The current trial hypothesizes that "Post-mastectomy radiation in high risk, node negative early breast cancer patients decreases rates of loco-regional recurrence and improves disease free … Dale Shepard, MD, PhD: So in terms of reaching out specifically to patients within breast cancer trials and breast cancer care, how big of a role does social media, patient support groups, how big of a role does that play in terms of patient awareness of a trial … Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. pp 7-40 | In addition to our many breast cancer trials, we offer trials for lung cancer, prostate cancer, ovarian cancer, and many more. The research team found that laser treatment may be a good treatment option for early stage breast cancer in the future. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Study Title: Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo Study Summary… 2017;377:122–31. N Engl J Med. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This study will help to determine if regional radiotherapy can be omitted for low risk ER positive node positive breast cancer patients. Ask whether the combination of drugs proposed for your chemotherapy have been through clinical trials Use of molecular tools to identify patients with indolent breast cancers with ultralow risk over 2 decades. N Engl J Med. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. Adjuvant pertuzumab and trastuzumab in early HER2-positive breast cancer. Brief Summary: This Phase II will evaluate a new type of breast cancer … Chordoma (closed to accrual 11 / 29 / 2018) 31. Angiosarcoma 51. 2002b;347(16):1233–41. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Effect of Radiotherapy After Mastectomy and Axillary Surgery on 10-year Recurrence and 20-year Breast Cancer Mortality: Meta-analysis of Individual Patient Data from 8135 Women in 22 Randomized Trials. J Clin Oncol. The Breast Cancer Prevention Trial (BCPT) was designed to see whether taking the drug tamoxifen (Nolvadex®) could prevent breast cancer in women who are at an increased risk of developing the … Citron M, et al. 2004;364:858–68. 2017;318(10):918–26. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. 213.144.97.145. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. Whelan T, et al. Investigators will test new tableted preparation, V3-MOMMO, obtained from hydrolyzed, inactivated blood and tumor tissues of patients with breast cancer. Clinical trials look at new ways to prevent, detect, or treat disease. It is not yet known whether radiation therapy with or without olaparib may work better in treating patients with inflammatory breast cancer. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Giving fulvestrant or exemestane with ribociclib may be an effective treatment for patients with breast cancer. 2017;3(11):1503–10. J Clin Oncol. © 2020 Springer Nature Switzerland AG. Trials measured cancer severity in terms of clinical stage (0 to IV), 23, 24, 68, 69 number of involved lymph nodes (0, 1 to 3, or ≥4), 18, 20, 25, 26, 70 and tumor size (mm), 19, 21, 26 and these varied across trials. These studies help improve the overall standard of care. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … For anti-HER2 management, five studies are discussed including the NSABP B-31, NCCTG N9831, HERA, CLEOPATRA, and APHINITY trials. Sarcomatoid carcinoma of lung 12. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. The Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741 and a meta-analysis by Mauri et al. SUNNYVALE, Calif., Jan. 19, 2021 /PRNewswire/ -- Accuray Incorporated (NASDAQ: ARAY) announced today that data from a prospective, phase II trial of 338 women with low-risk breast cancer … Breast Cancer Clinical Trials Death rates from breast cancer have reduced greatly in the last couple of decades, and that has been made possible in part thanks to the medical advances that resulted from clinical trials … It is not known whether patients with low risk breast cancer need to receive regional radiotherapy. Cleveland Clinic researchers are getting ready to embark on a clinical trial testing a breast cancer vaccine. Three exploratory single-agent cabozantinib (SAC) cohorts may also be enrolled with UC, NSCLC, or CRPC subjects. Location: 147 locations, This randomized phase III trial studies proton beam radiation therapy (proton therapy) compared to photon beam radiation therapy (photon therapy) in treating patients with breast cancer that has not spread to other places in the body (non-metastatic). Some breast cancer trials have temporarily stopped enrolling new patients. N Engl J Med. In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. The National Institute for Health and Clinical Excellence (NICE) provide guidance for women at higher risk of breast cancer. 2015;372:724–34. N Engl J Med. Fisher B, et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. https://doi.org/10.1007/978-3-030-14405-0_2. Location: 62 locations, This randomized phase II trial studies how well olaparib with or without atezolizumab work in treating patients with non-HER2-positive breast cancer that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection (locally advanced unresectable) or has spread to other places in the body (metastatic). JAMA. Chemotherapy drugs, such as cisplatin, carboplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The vaccine was developed by researchers at the Cleveland Clinic in Ohio and works by training the … At the moment they recommend that women at high or moderate risk of breast cance… Clinical trials … All trials on the list are supported by NCI. This trial; Search. Randomized data on chemoprevention • Prospective, double-blind, randomized trial • Involved 19,747 postmenopausal females and studied tamoxifen versus raloxifene in preventing breast cancer • The final analysis initiated after at least 327 incident invasive breast cancers were diagnosed: 163 and 168 cases of invasive breast cancer in tamoxifen and raloxifene treated groups • No differences were found for other invasive cancer … Kate Madden is the clinical research coordinator at Lexington … Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomized, multicenter, open label, phase 3 non-inferiority trial. Each treatment cycle lasts 21 days. The study consists of two stages: in the Dose Escalation Stage, an appropriate recommended cabozantinib dose for the combination with standard dosing regimen of atezolizumab will be established; in the Expansion Stage, tumor-specific cohorts will be enrolled in order to further evaluate the safety and efficacy of the combination treatment in these tumor indications. Management of breast cancer is changing rapidly. Location: 924 locations, This randomized phase III trial studies how well pembrolizumab works in treating patients with triple-negative breast cancer. Giving trastuzumab, vinorelbine tartrate, and avelumab with or without utomilumab may work better in treating patients with breast cancer. Every year researchers from more than 90 countries come together for the San Antonio Breast Cancer Symposium. SUNNYVALE, Calif., Jan. 19, 2021 /PRNewswire/ -- Accuray Incorporated (NASDAQ: ARAY) announced today that data from a prospective, phase II trial of 338 women with low-risk breast cancer … The Breast Cancer Locator study is a prospective, 1:1 randomized, controlled pivotal trial that will enroll 448 women with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS) … Clear cell ovarian cancer (closed to accrual) 46. N Engl J Med. Many studies have shown that women who are overweight or obese when diagnosed with breast cancer appear to have a higher risk of cancer recurrence. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. 4 mg/m 2 administered intravenously during 2–5 min on days 1 … Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Trastuzumab is a form of targeted therapy because it attaches itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomized controlled trial. Ask whether the combination of drugs proposed for your chemotherapy have been through clinical trials Location: 1201 locations, This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. It is not yet known if radiation therapy works better alone or with lymph node dissection in treating patients with breast cancer previously treated with chemotherapy and surgery. The vaccine was developed by researchers at the Cleveland Clinic in Ohio and works by training the … Esthenioneuroblastoma (closed to accrual) 44. Spindle cell carcinoma of kidney, pelvis, ureter 20. Vulvar cancer (temporarily closed to accrual) 36. Location: 21 locations, The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success. Sparano JA, et al. These trials relate to the multidisciplinary management of breast cancer from the perspective of a radiation oncologist. NSABP B-06: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. Basal cell carcinoma (temporarily closed to accrual 04 / 29 / 2020) 42. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. Swain S et al. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. evaluated the optimal sequencing of chemotherapy and are discussed. Over the past 40 years, breast cancer treatment has greatly improved due to lessons learned through clinical trials. J Clin Oncol. Cancer is a complicated disease, and many times it is hard to pinpoint the exact reason why it happened. For 2 years, Tyler participated in the trial that used a drug that had previously been used for stage 4 breast cancer patients. Continuing to provide our community with access to promising new therapies that may become tomorrow’s gold standard remains a top priority at RMCC. Lancet. The current trial hypothesizes that "Post-mastectomy radiation in high risk, node negative early breast cancer patients decreases rates of loco-regional recurrence and improves disease free … It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer. 2005;97:188–94. Location: 911 locations, This phase III trial compares the effect of cisplatin or carboplatin (platinum based chemotherapy) to capecitabine after surgery for the treatment of residual triple-negative breast cancer. Stopeck A, et al. Pheochromocytoma, malignant (closed to accrual) 25. Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual) 27. Location: 33 locations, This randomized pilot phase II trial studies how well fulvestrant with or without palbociclib and avelumab works in treating patients with hormone receptor positive, HER2 negative breast cancer that has spread to other parts of the body or that has come back after a period of improvement and cannot be removed by surgery, and have been previously treated with CDK and endocrine therapy. Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Proton therapy is a type of radiation therapy that uses multiple beams of protons (tiny particles with a positive charge) to kill tumor cells. The Breast Cancer Locator study is a prospective, 1:1 randomized, controlled pivotal trial that will enroll 448 women with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS) … Sentinel lymph node resection compared with conventional axillary lymph node dissection in clinically node negative patients with breast cancer: overall survival findings from the NSABP B-32 randomized phase 3 trial. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. It is not known whether giving olaparib with or without atezolizumab will work better in patients with non-HER2-positive breast cancer. Not logged in (closed to accrual) 23. Clinical trials are research studies that involve people. 2017;389:1195–205. Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Photon therapy is also a type of radiation therapy which uses multiple x-ray beams to kill tumor cells. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. NSABP-B04: Twenty-five year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. 2005;97(22):1652–62. US - Breast Cancer Clinical Trials … Cite as. Location: 15 locations, This randomized, phase II trial studies how well fulvestrant or exemestane with or without ribociclib works in treating patients with hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer that has progressed after treatment with an aromatase inhibitor or cyclin-dependent kinase 4 / 6 inhibitor (recurrent), cannot be removed by surgery (unresectable), or has spread to other parts of the body (metastatic). 2003;21:1431–9. The BRCA-P study will investigate if using Denosumab is a safe and effective way of preventing breast cancer. The study has randomized more than 10,200 women with this type of breast cancer at 1,182 sites in the … This chapter contains a summary of some key findings from a selection of 24 trials related to breast cancer. Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment. All trials on the list are supported by NCI. 2015;373:307–16. We searched PubMed and oncology congress websites (American Society of Clinical Oncology, San Antonio Breast Cancer Symposium, European Society of Medical Oncology) between Jan 1, 2000, and Sept 1, 2015, to identify clinical trials of CDK4/6 inhibitors in combination with adjuvant endocrine therapy for patients with oestrogen-receptor-positive, HER2-negative early breast cancer… Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Location: 1372 locations, This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. Not affiliated Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. Lancet. Regional nodal irradiation in early stage breast cancer. Due to the nature of this study design, some tumor cohorts may complete enrollment earlier than others. 2018;379:111–21. Esserman L, et al. NSABP trials were among the first to demonstrate that the oral hormonal therapy, tamoxifen, could reduce the risk of breast cancer recurrence and improve survival. Patients in this study will be randomly assigned to get either tucatinib or placebo (a pill with no medicine). Clinical trials test the safety and benefits of new treatments as well as new combinations (or new doses) of standard treatments. Trials measured cancer severity in terms of clinical stage (0 to IV), 23, 24, 68, 69 number of involved lymph nodes (0, 1 to 3, or ≥4), 18, 20, 25, 26, 70 and tumor size (mm), 19, 21, 26 and these varied across trials. for the CLEOPATRA Study Group. Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Kate Madden is the clinical research coordinator at Lexington … Monoclonal antibodies, such as pertuzumab, may interfere with the ability of cancer cells to grow and spread. This is a blinded study, so neither patients nor their doctors will know whether a patient gets tucatinib or placebo. The clinical trials on this list are for breast cancer. Gallbladder cancer 48. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. This randomized phase III compares weight loss interventions in treating overweight and obese women with a higher risk for breast cancer that comes back (recurrence). Apocrine tumors / extramammary Paget’s disease (closed to accrual) 40. 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